Abstract: Previous studies have shown that cataractous lenses exhibit characteristics of ferroptosis, including increased levels of oxidatively active iron, elevated lipid peroxidation, and a disrupted glutathione peroxidase system. Recent researches have confirmed that epithelial cells from age-related cataract lenses underwent ferroptosis. The use of agents like astaxanthin and melatonin can delay cataract formation by inhibiting the ferroptosis pathway. Additionally, the levels of lipid peroxidation and oxidative active iron in high myopia-associated cataracts have been found to be higher than those in age-related cataracts.

Key words: ferroptosis, cataracts/pathophysiology